Biostimulators - a holistic and natural trend in aesthetic medicine.
Aesthetic medicine is constantly evolving, offering new and more advanced solutions for the care of healthy and youthful looking skin. The fight against imperfections, blemishes and diseases such as acne, as well as the desire to help patients who do not accept their appearance and avoid their reflection in the mirror, has led to the emergence of new technologies that level the unfavorable appeal. One of the most rapidly gaining popularity are treatments using so-called biostimulators. In 2025, it is biostimulators that reign supreme in offices, providing an alternative or complement to traditional methods of improving skin condition. In this article, we will take a look at what biostimulators are, how they work, why they have become so fashionable, the specific benefits they bring to the skin, and discuss the costs associated with their use.
What are biostimulators and how do they work?
Biostimulators are preparations that, when injected under the skin, are designed to stimulate the body's natural regenerative processes - that is, to increase the production of collagen, elastin and other key components responsible for skin firmness and elasticity. Thanks to them, the skin gains the ability to rebuild itself, which translates into an improvement in its condition and appearance.
The mechanism of action of biostimulators is to induce a controlled inflammation at the site of administration, which initiates repair processes and enhances the synthesis of new support fibers. As a result, the skin becomes denser, tighter and smoother. Treatments of this type are often referred to as "collagen stimulators" - and for good reason, as stimulating fibroblasts to produce collagen is the key to their effectiveness.
The popularity of biostimulators in 2025 - what is the reason for the biostimulation fad?
Until a few years ago, the leading methods of rejuvenation were hyaluronic acid fillers and botulinum toxin. Nowadays, although still popular and frequently used, they are giving way to more natural methods of improving the appearance of the skin. This is for several reasons:
Natural effects
More and more patients are relying on treatments that produce subtle yet permanent results. Biostimulators do not alter facial features as markedly as classic fillers, but improve skin quality from within.Safety and long-lasting effects
Properly performed biostimulation treatment is relatively safe, and the effects can last up to 2 years. As a result, patients who do not want to visit an aesthetic medicine office too often are eagerly opting for this form of therapy.Growing awareness
Patient education about skin care and the long-term benefits of treatments is becoming more common. Those interested in improving their skin's appearance prefer methods that support its natural regenerative processes more than temporarily masking the signs of aging.Holistic approach to beauty
In 2025, the approach to beauty is based on health, prevention and harmony. Biostimulators are part of this trend, as they work in accordance with the body's natural biology, stimulating the production of key substances for the skin.
Effect of biostimulators on skin condition
The skin, subjected to biostimulation, becomes visibly firmer and smoother. This treatment:
Improves skin density by stimulating fibroblasts and increasing the production of type I and III collagen.
Increases hydration levels - certain biostimulants, including hyaluronic acid, have a beneficial effect on water binding in the skin, resulting in a fresher effect.
Strengthens protective barriers - regenerated skin is better able to cope with external factors such as UV radiation and environmental pollutants.
Equalizes skin tone and texture - stimulation of the synthesis of collagen and other support proteins helps minimize fine lines, scars or discoloration.
What's more, regular use of biostimulators helps keep skin looking healthy for longer, which is why many specialists recommend combining biostimulation with other treatments, such as peels or mesotherapy, to comprehensively improve skin condition.
Types of biostimulators in aesthetic medicine
There are several leading types of biostimulators on the market in 2025. The choice of a particular preparation depends mainly on the individual needs of the patient, age, skin quality, as well as expectations for the effect of the treatment.
1. polylactic acid (PLA)
Polylactic acid is a biocompatible and biodegradable substance that has been successfully used in medicine for years (including in orthopedic surgery for the production of dissolvable threads). In aesthetic medicine, PLA is used to stimulate collagen production by inducing low-grade inflammation in the tissues. The result is a gradual improvement in skin density and filling of defects in its structure. You have to wait a few weeks for results, but they last up to 24 months. Polylactic acid treatment is often recommended for people with visible signs of aging, such as skin sagging or loss of facial oval.
2. calcium hydroxyapatite
Calcium hydroxyapatite is a natural component of human bones and teeth, making it fully biocompatible. In the form of a preparation used in aesthetic medicine, it is in the form of a gel with microspheres, which have a two-step effect. The first effect is the immediate filling of wrinkles and furrows, and the second is the long-term stimulation of the skin to produce collagen. This results in a noticeable firming and thickening of tissues, and the result of the treatment lasts for an average of one to one and a half years. Calcium hydroxyapatite works especially well for those with advanced signs of aging and sagging skin.
3. polynucleotides
Polynucleotides are a relatively new group of biostimulants that are 2025 gaining increasing recognition due to their powerful regenerative effects. Extracted most often from salmonid fish material, they are highly effective nutrients that promote cellular renewal of the skin. Treatments with polynucleotides are recommended for patients with skin requiring intensive revitalization, with the first signs of aging or with acne scars. In addition to stimulating collagen and elastin production, polynucleotides improve microcirculation and hydration of the skin, making it more radiant and rested.
4. hyaluronic acid
Hyaluronic acid is probably the most recognized biostimulant. Present naturally in the human body, it is responsible for binding water in the skin, providing elasticity and firmness. Depending on the formula, in aesthetic medicine it can be used as a classic wrinkle filler or precisely as a stimulator of repair processes (in preparations of lighter consistency). Hyaluronic acid treatments give quick results, fill fine lines and hydrate the skin, as well as stimulate fibroblasts to produce collagen.
Costs of treatments with biostimulators
Prices for treatments with biostimulators vary depending on the type of preparation, the location of the office and the experience of the specialist. Approximate prices in 2025 in Poland are as follows:
Polylactic acid (PLA): from PLN 1,500 to 2,500 per ampoule. Usually 2-3 sessions are required, performed at intervals of about a month.
Calcium hydroxyapatite: from PLN 1,200 to 2,000 per ampoule. The number of ampoules depends on the treated area - usually 1-2 ampoules per session.
Polynucleotides: prices range from PLN 1,200 to 1,800 per treatment, depending on the concentration of the product and the number of applications needed (usually 2-4 treatments in a series).
Hyaluronic acid (as a stimulator): from 800 to 1500 zł per ampoule. On average, the effects last a few months, after which it is recommended to repeat the treatment.
It is worth remembering that the final cost may be higher if the doctor recommends performing a series of treatments to achieve optimal results. When choosing a facility, you should be guided not only by the price, but above all by the professionalism and experience of the doctor. Biostimulators, although considered safe, still require expertise and precision in administration.
